Dichotomizing High-Sensitivity Cardiac Troponin T Results and Important Analytical Considerations
نویسندگان
چکیده
منابع مشابه
Analytical validation of a high-sensitivity cardiac troponin T assay.
BACKGROUND We report the development of a novel high-sensitivity cardiac troponin T (hs-cTnT) assay, a modification of the Roche fourth-generation cTnT assay, and validation of the analytical performance of this assay. METHODS Validation included testing of analytical sensitivity, specificity, interferences, and precision. We established the 99th percentile cutoff from healthy reference popul...
متن کاملAnalytical characteristics of high-sensitivity cardiac troponin assays.
BACKGROUND Cardiac troponins I (cTnI) and T (cTnT) have received international endorsement as the standard biomarkers for detection of myocardial injury, for risk stratification in patients suspected of acute coronary syndrome, and for the diagnosis of myocardial infarction. An evidence-based clinical database is growing rapidly for high-sensitivity (hs) troponin assays. Thus, clarifications of...
متن کاملBiological and analytical variability of a novel high-sensitivity cardiac troponin T assay.
BACKGROUND High-sensitivity cardiac troponin assays will augment the frequency of increased results, making important the determination of reference change values to distinguish acute from chronic increases. We assessed short- and long-term biological variability of cardiac troponin T (cTnT) in healthy subjects with a novel high-sensitivity (hs) assay. METHODS We collected blood from 20 healt...
متن کاملHigh-Sensitivity Cardiac Troponin T and Risk of Hypertension.
BACKGROUND The diagnosis of hypertension is often preceded by cardiac structural abnormalities. Thus, we assessed whether high-sensitivity cardiac troponin T (hs-cTnT), a marker of subclinical myocardial damage, can identify individuals at risk for hypertension or left ventricular hypertrophy. METHODS AND RESULTS We studied 6516 Atherosclerosis Risk in Communities (ARIC) Study participants wh...
متن کاملHigh sensitivity cardiac troponin testing.
Bösner and colleagues have presented evidence for a simple rule for ruling out coronary artery disease in the primary care setting. It is noteworthy that no laboratory measurements have been included in their model, with reference to their introductory statement that “ ... electrocardiography and cardiac troponin test are of limited value in primary care... ” This point deserves some discussion...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2012
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2011.10.904